Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11→q22 region of chromosome 5. Bac...
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http://en.wikipedia.org/wiki/Dihydrofolate_reductase
<enzyme> An enzyme involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid. Inhibitors can be used as antimicrobial and anticancer drugs. Standard source is liver and the enzyme is used to assay dihydrofolate. ... (18 Nov 1997) ...
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http://www.encyclo.co.uk/local/20973
(= DHFR) An enzyme (EC 1.5.1.3) involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid, an essential vitamin cofactor in purine, thymidine and methionine synthesis. Inhibitors (eg. aminopterin and amethopterin, components of HAT medium) can be used as antimicrobial and anticancer drugs.
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(DHFR) Type: Term Pronunciation: dī-hī′drō-fō′lāt rē-dŭk′tās Definitions: 1. An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate. Synonyms: 5, 6, 7, 8-tetrahydro...
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http://www.medilexicon.com/medicaldictionary.php?t=24854
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